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CD58 (PNH Marker), in Ludhiana

This test measures the amount of CD58 protein on the surface of blood cells. Book CD58 (PNH Marker) in Sarabha Nagar, Ludhiana at GetVisit, NABL labs in Sarabha Nagar and Civil Lines, home collection, same-day results and cashless OPD.

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SAMPLE TYPE
Blood
FASTING REQUIRED
No
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Male/Female
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28 hours
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1
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What is a CD58 (PNH Marker) Test in Ludhiana ?

What is CD58 (PNH Marker)?

This test measures the amount of CD58 protein on the surface of blood cells. CD58 helps immune cells recognize and talk to each other. Physical examination provides clues; a test result removes ambiguity and allows targeted, evidence-based management to begin promptly.

What does CD58 (PNH Marker) measure?

Measuring CD58 can reveal abnormal or missing surface proteins on blood cells. Such changes may appear in paroxysmal nocturnal hemoglobinuria (PNH) and related bone marrow disorders. Doctors use CD58 together with other flow cytometry markers to help diagnose PNH, to check how active the disease is, and to monitor response to treatment. The test can be useful when someone has unexplained anemia, dark urine, or unusual blood clots.

What symptoms suggest CD58 (PNH Marker) may be needed?

A doctor may recommend CD58 (PNH Marker) when a patient reports any symptom your doctor has identified as requiring objective laboratory investigation, including unexplained fatigue, unexplained weight change, persistent pain, fever, or abnormal bleeding. Sample collection for Ludhiana is available at labs and at home across Sarabha Nagar, Civil Lines, and surrounding neighbourhoods.

How is CD58 (PNH Marker) performed?

This test needs a urine sample, not a blood draw. Collect a clean mid-stream sample in the sterile container GetVisit provides, ideally the first morning void, and hand it to the collection agent in Sarabha Nagar or Civil Lines, Ludhiana or drop it at a partnered lab. It is dispatched to the NABL-accredited lab and your digital report follows the same day for most routine urine tests.

How accurate is CD58 (PNH Marker)?

GetVisit's NABL-accredited labs serving Sarabha Nagar and Civil Lines, Ludhiana process urine samples on calibrated analysers under strict quality control. Accuracy depends on a clean mid-stream sample delivered promptly, so following the collection instructions is important. Reports are accepted by hospitals, specialists, and insurers across India.

Are there any risks to CD58 (PNH Marker)?

There is no medical risk. Providing a urine sample is completely non-invasive, with no needle and no discomfort. The only thing to get right is a clean collection: follow the container instructions to avoid contamination that could affect the result. Home collection in Sarabha Nagar or Civil Lines, Ludhiana is just as safe as visiting a lab.

Did you know?

PNH markers include flow cytometry demonstrating absent or reduced GPI‑anchored proteins (CD55 and CD59) on red cells and granulocytes.

CD58 (PNH Marker) Test Preparation in Ludhiana

Managing medication:

Continue your regular medicines unless your doctor has told you otherwise.

Fasting instructions:

Collect a clean-catch mid-stream sample in the container provided, ideally the first urine of the morning, and hand it in promptly for the most reliable result.

Timing:

An early slot works best, especially for fasting tests. Home collection is available across Salem Tabri, Sunet, and the rest of Ludhiana.

What to bring along:

Keep your prescription and ID handy, along with your OPD insurance details if applicable. Wear sleeves that roll up easily.

CD58 (PNH Marker) Test Parameters in Ludhiana

Single standalone test:

CD58 (PNH Marker). Can be ordered individually or as part of a preventive health package on GetVisit.

Why Take a CD58 (PNH Marker) Test in Ludhiana ?

When does a doctor order CD58 (PNH Marker)?

CD58 (PNH Marker) is usually part of a flow cytometry panel used to evaluate suspected PNH or related bone marrow disorders. Doctors may order it when a patient has unexplained anemia, fatigue, dark urine, or blood clots.

Who should get CD58 (PNH Marker) done in Ludhiana?

Ludhiana's large industrial workforce, ghee- and dairy-rich Punjabi diet driving high diabetes and cardiovascular prevalence, winter air pollution, and seasonal monsoon infections make regular preventive diagnostic testing an important habit for residents citywide. Adults above 30 in Ludhiana benefit from periodic health screening that includes CD58 (PNH Marker) as part of a broader preventive panel. Residents of Sarabha Nagar, Civil Lines, and across the city with chronic conditions, those on long-term medication, and individuals with a relevant family history should test at the frequency their specialist recommends.

What conditions can CD58 (PNH Marker) help diagnose?

The test helps detect blood cell clones that lack normal surface proteins. Abnormal results most often reflect an acquired condition such as PNH rather than lifestyle causes. A family history of bone marrow disease or unexplained hemolysis may make testing more important.

What do CD58 (PNH Marker) results mean?

Higher or positive results: PNH is typically Coombs-negative. Lower or negative results: PNH is typically Coombs-negative. Your doctor reads the value against the reference range on your report and your symptoms, and may repeat a borderline result to confirm it.

How often should CD58 (PNH Marker) be repeated?

For preventive screening with a normal baseline: annually for most adults above 35. For monitoring a known condition: at the interval your specialist recommends, typically every 3 to 6 months for active conditions and annually for stable, well-controlled ones.

What happens after your CD58 (PNH Marker) results are ready?

Results are delivered to your phone and stored securely on GetVisit. Any value the laboratory flags as critical is escalated for urgent review, and for everything else your doctor or a verified specialist can guide the next step at your convenience.

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Frequently asked questions

For any unanswered questions, reach out to our support team via email. We will assist you as soon as possible

What are the markers for PNH?plus

PNH markers include flow cytometry demonstrating absent or reduced GPI‑anchored proteins (CD55 and CD59) on red cells and granulocytes. Laboratory evidence of hemolysis, elevated LDH, indirect bilirubin, reticulocytosis, low haptoglobin and hemoglobinuria, is typical. Historical sucrose lysis or Ham (acidified serum) tests may be positive. Patients may also show marrow abnormalities or thrombotic markers (e.g. elevated D‑dimer).

What is CD55 and CD59 in PNH?plus

CD55 (decay‑accelerating factor) and CD59 (protectin) are GPI‑anchored complement regulators on red blood cells. In PNH, PIGA gene-mediated loss of GPI anchors removes CD55 and CD59, allowing unchecked complement activation. CD55 disrupts C3/C5 convertases; CD59 prevents membrane attack complex formation. Their absence causes intravascular hemolysis, hemoglobinuria, anemia and fatigue, with increased thrombosis risk.

What is the gold standard for diagnosing PNH?plus

The gold standard for diagnosing paroxysmal nocturnal hemoglobinuria (PNH) is flow cytometry demonstrating absence or reduced expression of GPI‑anchored proteins (especially CD55 and CD59) on red blood cells and granulocytes. FLAER‑enhanced flow cytometry (using fluorescent aerolysin) provides higher sensitivity and is preferred for detecting PNH clones in granulocytes and monocytes, confirming diagnosis and guiding management.

Is PNH Coombs positive or negative?plus

PNH is typically Coombs-negative. Hemolysis is complement-mediated due to loss of GPI-anchored proteins (CD55/CD59) on red cells, causing intravascular destruction without autoantibodies. Therefore the direct antiglobulin (Coombs) test is usually negative. Rarely, concomitant autoimmune hemolysis can yield a positive Coombs, but classic PNH is diagnosed by flow cytometry showing CD55/CD59 deficiency.

Do I need a doctor's prescription to book CD58 (PNH Marker)?plus

You can book CD58 (PNH Marker) on GetVisit with or without a prescription, though a doctor's advice helps with interpreting the result. Cashless OPD may require a referral, depending on your insurer.

Can menstruation affect CD58 (PNH Marker) results?plus

Some tests, such as iron studies and certain hormone panels, can be influenced by your menstrual cycle. If you are on your period, mention it so your doctor can judge whether timing matters for CD58 (PNH Marker).

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